KEGG analysis showed that DMR-related genes are mainly involved in metabolic pathway, pathways in cancer, cAMP signaling pathway, HTLV-I infection, cytokine-cytokine receptor interaction, calcium signaling pathway, alcoholism, regulation of actin cytoskeleton, hippo signaling pathway, Wnt signaling pathway, non-alcoholic fatty liver disease (NAFLD), insulin secretion, glycerophospholipid metabolism and type 2 diabetes mellitus (Figure 3B). The gene discussed is INS; the disease is alcohol dependence.