According to KEGG enrichment analysis, these overlapping genes were primarily involved in metabolic pathway, including metabolism of xenobiotics by cytochrome P450, steroid hormone biosynthesis, retinol metabolism, ascorbate and aldarate metabolism, pentose and glucuronate interconversions, porphyrin and chlorophyll metabolism, drug metabolism, starch and sucrose metabolism, chemical carcinogenesis, PI3K-Akt signaling pathway, MAPK signaling pathway, pathways in cancer and Rap1 signaling pathway (Figure 7B). This evidence concerns the gene RAP1A and cancer.