These N-glycan modifications are known to be catalyzed by the following glycosyltransferases: First, β-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) for bisecting, which has been previously reported to differentiate between iCCA and HCC in serum (38). The gene discussed is PRRT2; the disease is hepatocellular carcinoma.