IGF1 and type 2 diabetes mellitus: For CRC+ T2DM patients, sex, age, AGEs, RAGE, sRAGE, IGF1 and IGF1R were included to construct a multifactorial logistic regression analysis, and the results revealed that the effects of age, serum IGF-1 and IGF-1R on the occurrence of CRC in T2DM patients were statistically significant (all p < 0.05), while sex, serum AGEs and RAGE had no statistically significant effect on the development of CRC in patients with T2DM (all p > 0.05) (Figure 5).