IGF1R and type 2 diabetes mellitus: In our study, we also found that in CRC+ T2DM patients, serum AGEs were positively correlated with IGF-1 levels (r= 0.591, p<0.001) and negatively correlated with IGF-1R levels (r= -0.433, p=0.015), demonstrating that there may indeed be a correlation pathway between AGEs and IGF-1 and IGF-1R promoting an increased risk of CRC in T2DM patients.