YTH domain family 1 (YTHDF1), another m6A “reader”, directly binds to circRHBDD1 by acting as a circRHBDD1-interaction protein and subsequently binds to phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) mRNA, promoting translation of PIK3R1 and regulating metabolic rewiring and anti-PD1 therapy in HCC (109) (Figure 4Db). This evidence concerns the gene PIK3R1 and hepatocellular carcinoma.