ROC curve analysis established 21.25% as the cut-off value for MFC to distinguishing aggressive from indolent lymphomas (area under the curve =0.977, P < 0.001); Therefore, when this value was used, the positive rates of Ki67 expression could identify aggressive lymphomas with a sensitivity of 93.0% and a specificity of 99.6% (Figure 4C). The gene discussed is MKI67; the disease is lymphoma.