Included among the kinases in the body are 58 receptor tyrosine kinases (RTKs) which are important regulators of various cellular processes and pathways, and many anti-cancer drugs act as receptor tyrosine kinase inhibitors (RTKIs) for the treatment of colorectal cancer liver metastasis (CRLM) (10, 11) and HCC (12). The gene discussed is NTRK1; the disease is hepatocellular carcinoma.