In conclusion, our study provides, for the first time, absolute quantification of RTKs in liver tissue from healthy individuals and cancer patients with a focus on CRLM, reflecting a significant suppression of EGFR, INSR, VGFR3, and AXL, and upregulation of IGF1R, EPHA2 and PGFRB in tumour. This evidence concerns the gene INSR and neoplasm.