And the cooperation between JMJD1A and JMJD2A in regulating BHLHE40 transcription may be relevant to diseases other than cancer, including cardiac hypertrophy and fibrosis that are dependent on BHLHE40 (67, 68) and promoted by JMJD1A and JMJD2A overexpression (69, 70). Here, KDM4A is linked to cardiac hypertrophy.