BHLHE40 and colorectal neoplasm: In agreement with this, analysis of published microarray data (63, 64) revealed that BHLHE40 mRNA levels are upregulated in colorectal tumors (Figure 5A and Supplementary Figures 3A-D) and may be a predictor of disease recurrence (Figure 5B and Supplementary Figures 3E, F) and disease-free survival (Figure 5C).