Amongst those, we selected ADAM19, which encodes for a metalloproteinase, and KLF7, which encodes for a DNA-binding transcription factor, for further analysis, because their expression was positively correlated with BHLHE40 in 592 colon adenocarcinomas (Figures 6D, E) and little was known about their role in colon cancer. The gene discussed is BHLHE40; the disease is colon adenocarcinoma.