In the present study, we have discovered that BHLHE40 transcription is jointly stimulated by ETV1, JMJD1A and JMJD2A, that BHLHE40 can stimulate growth and clonogenic activity of HCT116 colorectal cancer cells, that KLF7 and ADAM19 are regulated by BHLHE40, and that KLF7 and ADAM19 are in their own right potential promoters of colorectal tumors. Here, KDM4A is linked to colorectal neoplasm.