Our transcriptomic analyses in HCT116 colorectal cancer cells showed that downregulation of BHLHE40 led more often to a reduction than an increase of gene transcription, suggesting that BHLHE40 is mostly stimulating transcription of genes, including KLF7 and ADAM19. If this is through direct DNA binding at respective gene promoters or other means remains to be studied. This evidence concerns the gene BHLHE40 and colorectal cancer.