VIM and cervical carcinoma: At the same time, Shen et al. also found that inhibition of PVT1 expression can significantly increase the expression of E-cadherin in CaSki cells, while the expression of fibronectin and vimentin significantly decreased, thereby increasing the sensitivity of CaSki cells to paclitaxel and high expression PVT1 can induce EMT transformation and make cervical cancer cells resistant to paclitaxel [31].