Like other lncRNAs, MALAT1 is also associated with oxidative stress-induced insulin resistance, as it suppresses insulin signaling by inhibiting the phosphorylation of IRS and Akt through the upregulation of the stress-sensitive kinase c-Jun N-terminal kinase (Jnk), which has been shown to negatively regulate insulin signaling. The gene discussed is INS; the disease is Insulin resistance.