In tilapia treated with the c‐Myc inhibitor 10058‐F4, the upregulation of c‐Myc expression in spleen lymphocytes during CD3 mAb stimulation (Figure S7C, Supporting Information) or bacterial infection (Figure S7D, Supporting Information) was markedly suppressed, which further impaired the upregulation of ASCT2, SNAT2, GLS1, and GLUD (Figure 6A; Figure S7E–G, Supporting Information). The gene discussed is MYC; the disease is bacterial infectious disease.