Consistent with our hypothesis, the levels of p‐P70S6K1 and p‐4EBP1 in the brain microvasculature of diabetic mice with specific gene knockout were significantly lower than those in the diabetes group, and the diabetes‐induced activation and induction of mTORC1 was significantly inhibited (Figure 5E,F). The gene discussed is EIF4EBP1; the disease is diabetes mellitus.