APP and Alzheimer disease: Compared with WT, APP/PS1 (AD) mice had significant impairment of memory and cognition, as indicated by the longer time required to reach the escape platform during the acquisition training (Figure 1A), the decreased number of crossings in the target quadrant (Figure 1B,C) in the MWM test, the shortened latency to enter the dark compartment in the step‐through test (Figure 1D), and decreased novel object exploration in the object recognition test (Figure 1E).