In 198 participants from PPMI database, after adjusting sex, years of education, and disease duration, age was significantly associated with motor symptoms (Hoehn & Yahr stages, Tremor scores, UPDRS‐III scores), non‐motor symptoms (scores of SCOPA‐AUT, LNS, BJLOT, SDMT, SFT, MoCA, and Immediate Recall of HVLT‐R), striatum SBRs, and p‐tau levels in CSF of PD patients (Table 1). Here, MAPT is linked to Parkinson disease.