NPPB and breast cancer: Although the investigations performed in breast cancer patients, not murine models, are limited it seems that exercise may increase left ventricular ejection fraction and cardiorespiratory capacity [23], decrease biomarkers such as Brain Natriuretic Peptide (BNP), high-sensitivity cardiac troponin and c-reactive protein [22, 24, 25] and blood pressure, and improve the sympathovagal imbalance increasing baroreflex sensibility and reducing resting heart rate [26, 27].