However, the discordance of gene expression was still observed between tumor cells from the different compartments, likely resulting from the different environments (e.g., expression of CRIP1 and KLF6) [64] or tumor cell aggressiveness and dissemination (detailed explanation in Mechanisms explaining MM trafficking through PB disease dissemination) [35, 65, 66]. This evidence concerns the gene CRIP1 and neoplasm.