Based on previous literature, there is a hypothesis that inflammation occurs in FTD patients with increased levels of proinflammatory markers (IL-1β, IL-2, IL-6, IL-12p70, IL-17A, IFN-γ, TNF-α, BAFF/TNFSF13B, TWEAK/TNFSF12, and sCD30/TNFRSF8) and decreased levels of anti-inflammatory markers (IL-4 and IL-10). This evidence concerns the gene TNFSF13B and frontotemporal dementia.