AKT1 and cancer: The data indicated that the NEDD8 gene signature derived from oral cancer tissues with low NEDD8 expression/cancer nonprogression significantly (p < 0.001) and positively correlated with the transcriptional levels of the gene set for MTORC1, whereas another NEDD8 gene signature from oral cancer tissues with high NEDD8 expression/cancer progression negatively correlated with the transcriptional levels of the gene set for the PI3K/AKT/MTOR pathway (Fig. 4B).