The data showed that NEDD8 mRNA levels significantly (p < 0.05) and negatively correlated with time to new tumor event in the TCGA HNSCC cohort with irradiation treatment (Fig. 2A) and overall survival time in GSE42743 oral cancer patients receiving radiotherapy (Fig. 2B). The gene discussed is NEDD8; the disease is head and neck squamous cell carcinoma.