Interactions between CD4+ T cells and B cells within tumours induce tumour-specific Tfh cell generation; afterwards, Tfh cells can enhance the antitumour effect of CD8+ T cells by secreting IL-21 [27] In addition, CD86+ B cells induce T-cell responses by localizing heavily in the TME through the presentation of tumour-associated antigens, particularly in TLSs of various cancer types, and B cells have also been found to promote the formation of TLSs by secreting CXCL13 and cytotoxic factors [28]. This evidence concerns the gene IL21 and neoplasm.