Together, these findings revealed that VDR-mediated signaling has a substantial impact on the proinflammatory capacity of microglia/macrophages by restricting the release of TNF-α and IFN-γ, which could further influence endothelial CXCL10 release, leukocyte infiltration, infarction evolution, and eventually functional outcomes following acute cerebral ischemia. This evidence concerns the gene TNF and infarction.