To determine whether VDR signaling in microglia/macrophages would have a specific impact on stroke progression and outcome, we generated inducible Vdr conditional knockout (Vdr-cKO: Cx3cr1CreER/+; Vdrf/f) mice by crossing Vdrf/f mice with Cx3cr1CreER mice (Additional file 1: Fig. S2A). This evidence concerns the gene VDR and Stroke.