Besides nanoparticle-based photothermal therapies, nanoparticle-based gene therapies, including chitosan derivatives micelle encapsulating pigment epithelium derived factor (PEDF) plasmid, and hyaluronic acid (HA) modified polyethylenimine-grafted chitosan oligosaccharide (CSO-PEI) compressing siRNA system, have also been shown to effectively inhibit endometriosis [29, 30]. This evidence concerns the gene SERPINF1 and endometriosis.