In this study, we have developed a prognostic prediction model for colon cancer based on 12 immune genes, including SLC10A2, FABP4, FGF2, CCL28, IGKV1-6, IGLV6-57, ESM1, UCN, UTS2, VIP, IL1RL2, and NGFR. This evidence concerns the gene ESM1 and malignant colon neoplasm.