Finally, to evaluate rescue of AML propagation, we transplanted lethally irradiated syngeneic mice with either E6KO MA9mock or E6KO MA9Flag-E6 cells and observed that among the recipient mice transplanted with E6KO MA9mock cells, very few recipients developed AML, as with Elovl6−/− MA9 cells (Fig. 2C). Here, ELOVL6 is linked to acute myeloid leukemia.