Here, we observe that influenza-induced sickness behaviours were similarly attenuated by 1) ibuprofen, aspirin and EP3 receptor antagonism, 2) Ptger3-targeted gene knockout using Advillin-creER, Phox2b-cre and Gabra1-IRES-cre mice, and direct AAV-cre injection in NJP ganglia, 3) ablation of GABRA1 NJP neurons, and 4) and glossopharyngeal nerve transection. The gene discussed is PHOX2B; the disease is influenza.