Cox regression analyses showed that age at diagnosis ≥ 59.5 (HR = 2.673, 95% CI: 1.588–4.499, p < 0.001), NLR ≥ 6.6109 (HR = 2.004, 95% CI: 1.193–3.368, p = 0.009), CAR ≥ 0.2506 (HR = 1.864, 95% CI: 1.041–3.339, p = 0.036), ferritin ≥ 397.68 (HR = 2.451, 95% CI: 1.245–4.827, p = 0.009) and anti-MDA5 antibody (HR = 1.928, 95% CI: 1.123–3.309, p = 0.017) were significant risk factors for all-cause mortality in IIM-ILD patients (Table 4). This evidence concerns the gene IFIH1 and interstitial lung disease.