Whereas previous broad screens included kidney-relevant biomarkers such as creatinine and cystatin C as two out of thousands of phenotypes, we used these biomarkers to estimate the most common clinical measure of kidney function, the GFR, compared and contrasted associations across different kidney function markers, and validated results by examining ICD-10 and biomarker-based binary phenotypes and kidney diseases. Here, CST3 is linked to kidney disorder.