SLC2A9 and gout: Among the 82 urate-associated variants, 16 mapped into a region on chromosome 4 that includes SLC2A9, and another 30 variants mapped into an extended region on chromosome 11 that includes SLC22A12. Consistent with the physiology of the urate-reabsorption mediating transporters encoded by these genes, the urate-associated variants had a negative effect on urate levels and showed strong protection from gout.