ARHGEF16 and kidney disorder: There were two genes that have not yet been described as causative for monogenic kidney diseases in humans, but for which genetically manipulated mice show a kidney disease phenotype, namely ARHGEF16 and FNIP1. Little is known about Rho Guanine Nucleotide Exchange Factor 16, encoded by ARHGEF16. Phenotypic characterization of genetically manipulated mice in the Mouse Genome Informatics resource showed enlarged kidneys and abnormal kidney morphology (MGI: 2446219).