The interactive network elucidated that the main active ingredients of AM may act on IL-17 signaling pathway, Th17 cell differentiation, Necroptosis, NOD-like receptor signaling pathway, Kaposi's sarcoma-associated herpesvirus infection and VEGF signaling pathway through PTGS2, STAT1, HSP90AA1 and other targets, which are involved in the therapeutic effects of AM on vitiligo and COVID-19. This evidence concerns the gene HSP90AA1 and COVID-19.