Recently, a specific role for terminal deoxynucleotidyl transferase (DNTT) in the acquisition of NPM1 mutations and FLT3 internal tandem duplications has been hypothesized in AML44,45, and our data linking this gene specifically to the LSC compartment may further support a role of LSCs for the development and progression of AML. Here, FLT3 is linked to acute myeloid leukemia.