MYC and acute myeloid leukemia: In NPM1mut AML, we were able to discriminate a regenerative response within the more committed blast compartment from a rare subpopulation of LSCs that expressed master regulators of a WNT-MYC developmental program37, showed an inflammatory response, persisted in a quiescent state upon chemotherapy and correlated with increased LIC frequency in serial xenografts, which would have been missed if residual AML were analyzed in bulk.