NOS3 and endothelial dysfunction: In other pathological contexts of endothelial dysfunction, several interventions havebeen researched in an effort to prevent or minimize this dysfunction, includingphysical exercises.(6,7) Physical exercise has been shown tostimulate endothelial cells by increasing shear stress.(8,9) Morespecifically, the local blood flow augmentation, in response to physical exercise,promotes an increase in the frictional force on the vessel wall, triggering theactivation of eNOS by endothelial cells, NO release and a vasodilation response.