ACE2 and hypertrophic cardiomyopathy: As such, observations from this reduced, ACE2-accentuated model system may reflect potential pro-arrhythmic susceptibility, not in the normal, healthy host, but rather in the patient who has other co-morbidities that trigger up-regulation in ACE2 levels in the heart such as hypertension and hypertrophic cardiomyopathy [27, 28].