However, in those who present with signs of thyroid eye disease or whose thyrotoxicosis persists for more than 4 weeks, we recommend checking TSH receptor antibodies and/or a thyroid uptake scan, and consider antithyroid drugs such as carbimazole if positive or in persistent thyrotoxicosis, due to the rare occurrence of Graves’ disease. The gene discussed is TSHR; the disease is thyrotoxicosis.