Two or more depleted pituitary axes, reflected by hormone levels below the normal range of target glands (thyroid hormones, etc.)and low or inadequately normal pituitary hormone levels indicate hypopituitarism (with or without hypophysitis), whilst low cortisol and aldosterone levels with compensatory elevation in ACTH levels and in renin levels or renin activity correspond with primary adrenal failure due to adrenalitis. The gene discussed is REN; the disease is hypophysitis.