Exploratory analyses using a modified 5P risk score found significant differences in PedsQL-4.0 scores between the PTH-M and no PTH groups for total (EMD, −3.49; 95% CI, −5.88 to −1.10; P = .03) and physical functioning (EMD, −4.32; 95% CI, −7.19 to −1.44; P = .02) scores, and between PTH-M and OI groups for school functioning (EMD, −4.55; 95% CI, −7.66 to −1.43; P = .03). This evidence concerns the gene PTH and osteogenesis imperfecta.