AD hyper-IgE syndrome caused by dominant negative variants in STAT3 (i.e., Job’s syndrome or STAT3 LOF) is the best characterized of these conditions, but this list of disorders also includes other AD (IL6ST; Beziat et al., 2020) and autosomal recessive (AR; ZNF341 [Béziat et al., 2018], IL6ST [Shahin et al., 2019]) disorders (Bergerson and Freeman, 2019; Minegishi, 2021). Here, ZNF341 is linked to Alzheimer disease.