Therefore, it is necessary to detect the expression levels of PD-1, PD-L1, and CD8 + TILs in the Chinese population of patients with OPSCC, so as to provide a theoretical basis for better clinical prognosis of HPV + patients and provide baseline data for the application of PD-1/PD-L1 in head and neck tumors. This evidence concerns the gene CD274 and head and neck neoplasm.