While the anti-DRiP1-13 antiserum specifically detected the INS-DRiP polypeptide recognised by cytolytic T cells in individuals with type 1 diabetes, the anti-SPLICE81-95 antiserum reacted with both recombinant INS-DRiP and INS-splice proteins (ESM Fig. 2). This evidence concerns the gene DORIP1 and type 1 diabetes mellitus.