Therefore, we compared the frequency of annexin V+ CD8 T cells from LD and HD mice at week 2 p.i. Interestingly, Ag+ (CD44hiCD11ahi) CD8 T cells from LD-infected mice were significantly more apoptotic at weeks 2 and 5 p.i. as compared with mice that received an HD infection (Fig. 2A, 2B). This evidence concerns the gene ANXA5 and Huntington disease.