CSF1 and breast cancer: Interestingly, Kindlin-2 has been reported to control the recruitment of immunosuppressive (F4/80+, CD206+) macrophages in orthotopic breast cancer models; Kindlin-2 in the tumor cells is required for the secretion of colony-stimulating factor-1 that acts as a chemoattractant for the macrophages (Sossey-Alaoui et al., 2017).