COLEC11 and melanoma: The protumor roles of CL-11 are supported by several findings of our study, these include: (a) melanoma growth is suppressed in Colec11–/– mice; (b) CL-11 is required for melanoma cell proliferation, angiogenesis, and establishment of more immunosuppressive TME; and (c) CL-11 induces mitogenic kinase signaling and stimulates melanoma cell proliferation in vitro.