COLEC11 and melanoma: Therefore, although the observation of upregulation of COLEC11 expression in human melanomas alone can be interpreted as “causative” or “consequence,” which — together with the findings that CL-11 has stimulatory effects in human melanoma cell proliferation, melanoma growth is suppressed in Colec11–/– mice, and high COLEC11 expression has a trend toward poor survival — would support a pathogenic role for CL-11 in human melanoma.