Upregulation of procancer genes (Spp1, Igf1, Plgs2, Plau, Ctsk, Areg, Hbegf, Il1a, Ilb) was found in TAM-WT compared with TAM-KO, and this aligns with the observation that CL-11 is required for tumor cell proliferation, tumor growth, and angiogenesis. This evidence concerns the gene IGF1 and neoplasm.