Likewise, Malat1–/– mice showed impaired cardiac function, as assessed by significantly decreased ejection fraction 21 days after MI when compared with Malat1+/+ mice (Figure 1, G and H, and Supplemental Videos 1 and 2; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.162124DS1). This evidence concerns the gene MALAT1 and myocardial infarction.