In line with these results, chemerin administration was found to exert an antiinflammatory action associated with the increased infiltration of macrophages in a model of lung inflammation (13), and depletion of intestinal mononuclear phagocytes in a DSS-induced colitis model was shown to increase colitis severity owing to a higher infiltration of MPO+ neutrophils (62). Here, RARRES2 is linked to colitis.