This study investigated the role of the chemerin/CMKLR1 axis in GvHD, using a well-known MHC-mismatched murine model (30) based on the use of BALB/c (H-2d) as recipient mice and C57BL/6 (B6; H-2b) mice as allograft donors. This evidence concerns the gene RARRES2 and graft versus host disease.