Furthermore, we present unexpected predictive models of several DDR deficiencies; ATRX and IDH1 deficiency in cancers of the central nervous systems (CNSs), HERC2 and CDKN2A deficiency in skin, PTEN deficiency in cancers of the CNS and uterus, and SMARCA4 deficiency in cancers of unknown primary. The gene discussed is HERC2; the disease is cancer.