We divided the models into four groups based on aetiology and origin: models of BRCA1/2-d (eight models of BRCA2-d and a single model of BRCA1-d; Figure 3b); models of monoallelic TP53-d (11 models; Figure 3c); models of various monoallelic gene deficiencies derived from colorectal cancer patients (eight models; Figure 3d); and models including other DDR genes and cancer types, including previously undescribed associations (20 models; Figure 3e). The gene discussed is BRCA1; the disease is colorectal cancer.