We found that ATRX-d (monoallelic: PR-AUC-E = 0.21, AUROC = 0.71; biallelic: PR-AUC-E = 0.23, AUROC = 0.76; Figure 6a) and IDH1-d (monoallelic: PR-AUC-E = 0.24, AUROC = 0.82; Figure 6b) in CNS cancers were both predicted by a decreased number of SBS signature 8 mutations. The gene discussed is ATRX; the disease is central nervous system cancer.