HERC2 and skin cancer: We found HERC2-d predictable in HMF skin cancer patients (biallelic: PR-AUC-E = 0.24, AUROC = 0.73; monoallelic: PR-AUC-E = 0.23, AUROC = 0.66; Figure 6e), primarily based on enrichment of deletions in non-microhomologous and non-repetitive regions.