TP53 and neoplasm: As expected, TP53 deficiency (TP53-d) was the most frequent LOF event (81 biallelic and 1746 monoallelic events; 29% of tumours affected; Supplementary file 1b; Figure 1d), while 70% of DDR genes had biallelic deficiency in less than 10 tumours across all cancer types (511/736; Figure 1d).