SMC2 and colorectal cancer: In the HMF colorectal cancers, we discovered eight predictive gene deficiency models (MSH3, SMC2, SMC6, BMPR2, CLASP2, SRCAP, UBR5, and UVRAG) of monoallelic LOF with PR-AUC-E ranging from 0.21 (CLASP2) to 0.62 (MSH3) (AUROC ranging from 0.68 for SRCAP deficiency to 0.94 for MSH3 deficiency; Figure 4j–l).