Mutations in genes encoding subunits of the SWI/SNF complex are also present in other tumours, including gliomas, medulloblastomas, and squamous cell carcinomas,3, 58, 59 where mutations in SWI/SNF complex subunit genes include mutations in BRG1 and, to a lesser extent hBRM.58 The gene discussed is SMARCA1; the disease is glioma.