GSK3B and gastric cancer: IGHG1 overexpression has also been reported for the induction of epithelial to mesenchymal cell transmission (EMT) in gastric cancer via tumor growth factor beta (TGF-β)/SMAD3 signaling, whilst AKT/glycogen synthase kinase 3 beta (GSK-3β)/β-catenin pathway is also highly active [12].