Moreover, several other variants have previously been associated with differences in EDSS for MS patients, including rs17445836 in interferon regulatory factor-8 gene (23), rs3087456 and rs4774 in class-II trans-activator gene (24), rs1049269 in transferrin gene (25), and rs1494555 in interleukin-7 receptor gene (26). Here, IRF8 is linked to myeloid sarcoma.