A2M and chronic obstructive pulmonary disease: Luo et al. (2020) found that a non-coding RNA named LINC00612, dropped in COPD tissues and could regulate inflammation, oxidative stress, and apoptosis in human pulmonary microvascular endothelial cells via targeting miR-31-5p/NOTCH1 axis. Interestingly, our previous studies analyzed and identified dysregulation of LINC00612 in patients with COPD, and LINC00612 was co-expressed with alpha-2-macroglobulin (A2M) (Qian et al., 2018).