This phenotype deteriorated with age and depended on HIF1A but not HIF2A (black arrows in Fig. 5a,b) and, thus, on the same HIF isoform that drives retinal degeneration in \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$rod^{\varDelta \ Vhl}$$\end{document}rodΔVhl mice [31]. This evidence concerns the gene EPAS1 and retinal degeneration.