TP53 and mantle cell lymphoma: For MCL cell lines, CDC20 expression was significantly upregulated in all the four cell lines at mRNA (Fig. 1E) and protein (Fig. 1F) levels compared with healthy PBMCs, and CDC20 expression of p53-mutant cells Jeko and Mino was higher than that of p53-wild type cells Z138 and JVM2 (Fig. 1F).