Expectedly, the abilities of cell migration and invasion was significantly attenuated (Fig. 5G and H) with the decreased expression of MMP2 and MMP9 proteins (Fig. 5I) in Z138 and JVM2 cells treated with nutlin-3a compared with the control group, further proving that p53 activation had inhibitory effect on MCL cell motilities. Here, TP53 is linked to mantle cell lymphoma.