In fact, the impairment of the composition of the organic portion of the bone was reported in animal models (e.g., DMP-1) [9, 10] and patients (e.g., collagens and osteocalcin (OCN)) [11–13] with osteoporosis, as well as a structural/orientational alteration of the fibrils [10, 14, 15]. Here, BGLAP is linked to osteoporosis.