Further, past work has associated higher prolactin levels with increased risk of more aggressive tumors (e.g., > 2 cm, higher grade, and positive lymph nodes) [5], and pSTAT5 can be overly activated by cytokines leading to more aggressive breast cancer phenotypes, although research is limited in evaluating these associations by menopausal status [17]. The gene discussed is PRL; the disease is breast carcinoma.