Ding et al. found that the overexpression of piRNA-823 promotes the expression of DNMTs, such as DNMT1, DNMT3A and DNMT3B, and thus inducing the hypermethylation of gene adenomatous polyposis coli (APC), inducing the stemness of luminal breast cancer cells by triggering Wnt signaling pathway [108]. Here, APC is linked to breast carcinoma.