Similarly, as a negative prognosis index in DLBCL patients, piRNA-30473 is overexpressed in DLBCL, and it regulates m6A methylation level by regulating the expression of WTAP, together with IGF2BP2, one of the m6A readers, which can up-regulate the expression of HK2 targeted at 5’UTR of its mRNA in cells by increasing stability of HK2 mRNA. This evidence concerns the gene WTAP and diffuse large B-cell lymphoma.