We concluded that, although PMPs can modulate phenotype of CRC cells to become more migrative/invasive and have less effect on strongly mesenchymal-like cancer cells, it is not linked to the ability of PMPs to transfer CXCR4 into cells and cannot be attributed to the increased effectiveness of the CXCR4/SDF1 axis. Here, CXCL12 is linked to colorectal carcinoma.